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However, persons with T1DM have trouble controlling their blood glucose levels

KL-la is the predominant lactylation form in cells and contributes to glycolysis and the Warburg effect (Zhang D

Recommended starting dose: Discontinue other basal insulin and/or GLP-1 agonist before initiating Xultophy Patients nave to basal insulin or a GLP-1 agonist: starting dose is 10 units once daily Patients currently on basal insulin or a GLP-1 agonist: starting dose is 16 units once daily Maintenance: titrate dose up or down by 2 units once or twice weekly, depending on blood sugar goals Missed doses: resume dosing at the next scheduled dose

doi: 10.1007/s00401-013-1230-6