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A 2021 clinical trial published in The New England Journal of Medicine the STEP 1 trial showed that participants on semaglutide lost an average of 14.9% of body weight, but research on the body composition breakdown of that loss suggests a meaningful proportion can come from lean mass rather than fat, particularly when protein intake is inadequate

A 2025 perspective suggested GLP-1s may influence epigenetic processes involved in age-related liver fibrosis and cancer risk [6]

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