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If you experience sharp, localized abdominal pain or fever, you should contact your healthcare provider immediately

All TPP-dependent enzymes contain a highly similar TPP-binding domain and its lack in the TKTL1 encoded protein strongly suggests that it is unlikely that TKTL1 is a TPP-dependent protein capable of catalyzing the transketolase reaction

Adjusting Schedules for Nerve-Related Symptoms If your B12 deficiency has progressed to the point where youre experiencing nerve-related symptoms like tingling or numbness in your hands and feet, your treatment plan will need to be more intensive

However, because it contains the same active ingredient as other medications approved for weight loss, many healthcare providers prescribe it off-label for that purpose