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They include - Nausea (the most common one across both) Constipation Diarrhoea Fatigue, particularly in early weeks Unique side effects to the pill - In OASIS 4, vomiting was notably more common with the pill than typically reported with the injection: Nausea: 46.6% (pill) vs 18.6% (placebo) in OASIS 4 Vomiting: 30.9% (pill) vs 5.9% (placebo) - higher than usually seen with the needle version Discontinuation due to adverse events: 6.9% with the pill, similar to the injection Fasting could be the main reason behind the higher vomiting rates

Briefly, mouse skin was shaved, and a fluorescent signal measuring device (Transdermal GFR monitor, MediBeacon) was attached with an adhesive patch

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3.9 Central nervous system (CNS) Headache is reported in GLP-1 receptor agonist trials ( Table 8 , in the Appendix)