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GLP-1 increased the expression of mRNA and transcription factors that play a part in the pleiotropic effects such as DNA synthesis in pancreatic beta cells, metabolic enzyme gene expression, and insulin biosynthesis

Doctors who treat obesity say the initiative, Medicare GLP-1 Bridge, could help millions of older adults who, like Kathryn, struggle to pay for the drugs or could not afford to even start taking them but said that questions remain about the federal governments administration of the program

Newer studies cite even more benefits of these medications, reducing obesity-related disorders like sleep apnea and other metabolic dysfunctions

Nature 581 , 434443 (2020)