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The Effects of GLP-1 Receptor Agonists on Body Composition in Patients With Type 2 Diabetes, Overweight or Obesity: A Meta-Analysis of Randomized Controlled Trials

Thus, the different volume regulation by SGLT2-I may limit the aberrant neurohumoral and RAAS stimulation that occurs in the setting of volume depletion ( Antihypertensive effects of SGLT2-i, which have been reported in clinical trials, are presumably due to their natriuretic effect

10 Furthermore, the anti-inflammatory properties and cytokine-modulating effects of GLP-1 RAs appear to contribute to pain regulation, implying a supplementary therapeutic modality

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