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Although TRT is widely accepted, it is not without drawbackscomplications such as erythrocytosis, worsening of obstructive sleep apnea, and increased cardiovascular risk have been reported [1]

Notably, its weight-reducing efficacy in patients with common obesity is superior to that of other GLP-1 RAs [73-75]

As more public figures connected weight changes to pregnancy, menopause, diabetes, or longterm struggles, the tone shifted

More recently, the European Medicines Agency Pharmacovigilance Risk Assessment Committee concluded that the available evidence does not at present support a causal association between GLP-1RAs and suicidality 237