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Neither route has a completed human safety profile

However, injectable vitamin B12, often prescribed to treat serious deficiencies, can cause the following side effects: mild diarrhea itching skin rash headache dizziness nausea vomiting pulmonary edema and congestive heart failure early in treatment vein thrombosis sensation of swelling polycythemia vera (rare, slow-growing blood cancer) Moreover, in rare cases, vitamin B12 can cause serious allergic reactions (anaphylaxis)

Kolovrat et al., 2020) can be foreseen

Some women experience rapid symptom escalation, while others have stable symptoms for years before sudden worsening