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*J Physiol Pharmacol.* 69(3)

In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)

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The trade-off is precision: the smaller the microgram per IU, the more forgiving the syringe granularity, but the larger the injection volume per study event