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Patients entered a run-in treatment period on glimepiride (4 mg per day) alone or glimepiride in combination with metformin HCl (1500 mg per day)

A very interesting paper describing a retrospective cohort analysis entitled "Peri-Procedural Safety of GLP-1 Receptor Agonists in Elective Endoscopy: A Multicenter Retrospective Cohort Study" just published in Journal of Clinical Medicine by Harsimran Kalsi and colleagues

First, they reduce injection-related barriers for patients who are hesitant to start weekly injectable treatment

Research shows that a significant proportion of weight lost on GLP-1 medications can come from lean mass, with estimates suggesting up to 3040% of total weight loss may be muscle and bone density, rather than fat (Neeland et al