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In fact, long-term use is associated with sustained weight loss and significant cardiovascular risk reduction

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The conversion of light into optic perceptions being transmitted to the brain via the optic nerve happens in the rods by its association to the protein opsin consequently forming rhodopsin, before 11- cis -retinal gets photo-isomerized to all trans retinal by the absorption of light [83, 100,101,102]

42 Likewise, a systematic review of 41 studies involving overweight or obese participants showed a significant reduction in total-hip BMD (0.0100.015 g/cm 2 ) after weight-loss interventions lasting six months or longer, whereas lumbar-spine BMD remained stable