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Whole-Cell ELISA Whole-cell ELISA was performed as described previously ( M Cell-Targeting Property Analysis The M cell-targeting properties of LL-plSAM-FVpE and the SAM-FVpE protein were performed as described previously with slight modifications ( Prophylactic and Therapeutic Immunization For prophylactic immunization ( Figure 1A ), the SPF BALB/c mice (6 to 8 weeks old, male) were randomly divided into 4 groups (n = 10): LL-plSAM-FVpE, LL-plSAM, SAM-FVpE plus PA adjuvant, and SAM plus PA adjuvant

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Microneedling initiates collagen induction at the scar depth