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When combination therapy is needed, clinicians often start with metformin and add a DPP-4 inhibitor if targets are still unmet

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doi: 10.5152/tjg.2015.0427 43 Munoz PenaJMCusiK

Peroxynitrite can oxidize a wide variety of biomolecules, which, in turn, modulates cell signal transduction pathways, interferes with mitochondrial function, impairs DNA, and finally mediates necrosis and apoptosis in different cell types ( Studies have shown that organisms can activate a series of defense responses, such as improving the activity of antioxidant enzymes in the body and initiating lysosomal degradation pathways, to prevent oxidative damage