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The prevalence of NAFLD is high in people with insulin resistance (IR), who may suffer from obesity, type 2 diabetes mellitus, dyslipidemia, and metabolic syndrome [1,2,3, 16, 18]

We uncovered the roles of these enzyme in catalyzing amide bond formations during the biosynthesis of 1 and analogs

In particular, strong connections between mitochondria and the chromosome ends, the telomeres, led to propose a new theory of ageing in which dysfunctional telomeres and mitochondria are the main actors of a vicious circle reducing cell fitness and promoting cellular ageing