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Effects of dapagliflozin on development and progression of kidney disease in patients with type 2 diabetes: an analysis from the DECLARE-TIMI 58 randomised trial
Studies tracking radiolabeled peptide demonstrate metabolism primarily in plasma, with resulting amino acids entering normal metabolic pathways
Moreover, islets extracted from high cholesterol-fed mice showed decreased exendin-4-induced cAMP responses ex vivo (Supplementary Figure 1A), suggesting a direct impact of increased cholesterol levels on GLP-1R signalling
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