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13 Fumarates and Co-medication There is no evidence for FAE interaction with cytochrome P450 and the most common efflux and uptake transporters, 7 and therefore no interactions are expected with medicinal products metabolised or transported by these systems

For example, in studies of the 2 -adrenergic receptor, an inverse agonist not only suppressed the constitutive activity of the receptors but also activated MAPK via a -arrestin2-dependent mechanism (Azzi et al., 2003)

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