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MDHAR, MDAR1 and ATMDAR2 catalyze the conversion of monodehydroascorbate to ascorbate (Chew et al., 2 O 2 -scavenging enzyme and a crucial component in reactive oxygen network (Tanaka et al., 2005)
It activates genes associated with collagen production, wound healing, anti-inflammation, and tissue remodeling
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A recent study demonstrated the ability of a dendrimer-conjugated NAC (D-NAC) to specifically target glial and astrocyte cells, indicating potential to alter GSH levels in specific cell populations without altering levels throughout the CNS ( One of the most well-established properties of GSH is its role in maintaining redox homeostasis, but it is also emerging as a mediator of redox signaling through mechanisms such as protein S-glutathionylation and/or GSNO-mediated protein S-nitrosylation (Zhang and Forman, 2012)
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