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Kidney transplantation is regarded as the optimal treatment for ESRD, providing superior survival and quality of life compared with dialysis [10, 166]

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C., Zelli, D., Svenningsson, P., McEwen, B

In this aspect, it has been reported that the blockade of 2 -adrenoreceptor by yohimbine aggravated oxidative stress induced by lipopolysaccharide (LPS) in the liver [30] as well as in the nervous system [34,35], while dexmedetomidine attenuated LPS-induced deleterious effects