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Additionally, some users have experienced gastrointestinal issues such as nausea and diarrhea, which, while often temporary, can affect adherence to the medication

Fails completely on GLP-1 medications because hunger signaling is pharmacologically suppressed

He experiences occasional episodes of mild hypoglycemia with his current sulfonylurea (glimepiride) therapy but is more concerned about progressive weight gain and feeling fatigued

Dose-response network meta-analysis of gastrointestinal adverse events with GLP-1 receptor agonists, 39 randomised trials and 33,354 non-diabetic participants with overweight or obesity