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Copper peptides alter gene expression broadly: one in-vitro analysis attributed to Loren Pickart and colleagues found GHK-Cu modulating expression of over 4,000 human genes, a finding that is mechanistically interesting but does not translate directly to proven clinical benefit

These mediators include -melanocyte stimulating hormone (-MSH), adrenocorticotropin hormone (ACTH), -endorphin, bFGF, endothelins, HGF and SCF[35]

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