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This sequence signature allowed us to investigate patients of the HCV Research UK cohort containing HCV sequence information and detailed clinical annotations for more than 2000 patients, mainly infected with the major HCV gts 1a, 1b and 3a 36

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This is particularly relevant given the role of the brain stem in regulating the vagal pathway and the cholinergic antiinflammatory reflex (14), suggesting a possible yet under-investigated neuroimmune link

The MHRA is encouraging healthcare professionals to report suspected cases through the Yellow Card scheme to support this research