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And there is a countervailing consideration the frequency logic tends to omit: more frequent stimulation of the ghrelin receptor raises the theoretical prospect of desensitization over time, so more pulses per day is not straightforwardly more effect, even on the models own terms

Source: Jastreboff et al., NEJM 2023 TRIUMPH-4 Phase 3 (68 weeks, 445 participants) Phase 2 Type 2 Diabetes Trial (36 weeks, 281 participants) In the type 2 diabetes population, weight loss was lower than in the obesity trial which is consistent with the pattern seen across all GLP-1 drugs

Source 2 Male and female age 45 years and older = 8 to 38 units/L (8 to 38 IU/L) Female younger than 45 years = 5 to 27 units/L (5 to 27 IU/L) Older people = Slightly higher than the adults Newborn = 5 times higher than adults

This isnt a side effect in the traditional sense