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Apply as frequently as needed

The inhibition is competitive glutathione competes with tyrosine (the amino acid tyrosinase acts on) for enzyme binding sites which is why the relationship between dosing, delivery method, and effect is not linear

Remnant livers (right lateral and caudal lobes) and blood samples (collected from retro-orbital sinus under anesthesia before killing) from three to seven mice per genotype were harvested at various time points from 30 min to 7 days