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Of the entire study population, 41 patients (47.7%) had cardiac outcomes, 12 patients (13.9%) had gastrointestinal outcomes, 22 (25.7%) had neurological outcomes, 7 patients (8.1%) had renal outcomes, 2 patients (2.3%) had gynaecological outcomes, and 2 patients (2.3%) had dermatological outcomes

If denied, the most common reasons are: Insufficient metformin trial duration (submitted 60 days instead of required 90 days) Missing A1C lab result from past 90 days A1C below 7.0% (Ambetter considers diabetes "controlled" and does not approve intensification) Diagnosis code submitted as E11.9 (unspecified diabetes) instead of more specific code A study by the American Diabetes Association (Gabbay et al., Diabetes Care 2024) found that prior authorization denials for GLP-1 receptor agonists were overturned on appeal in 71% of cases when resubmitted with complete documentation

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Chem Biol Interact 191:330338 Stirban A, Negrean M, Stratmann B (2006) Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes