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Targeting NRF2 sensitizes esophageal adenocarcinoma cells to cisplatin through induction of ferroptosis and apoptosis

In isolated PACs, MitoQ and the control cation Decyl-TPP increased basal respiration, but markedly reduced ATP-linked respiration, increased proton leak, and promoted both apoptosis and necrosis in a concentration-dependent manner, reflecting deleterious perturbation of mitochondrial bioenergetics rather than simple antioxidant protection (85)

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