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The primary end point was the percent change in low density lipoprotein cholesterol at twenty four weeks

Based on typical FDA review timelines and the current progress of trials, analysts project: Phase 3 trial completion: Late 2025 to early 2026 FDA submission: First half of 2026 Potential FDA approval: Q3 2026 to Q1 2027 Commercial availability: 2-3 months post-approval The FDA has not granted any special designations (Breakthrough Therapy, Fast Track) for Retatrutides obesity indication, which may mean standard review timelines apply

The most common are gastrointestinal: nausea, vomiting, diarrhea, and constipation

doi: 10.1155/2018/4020492