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Data from randomized controlled trials suggest that withdrawing either glucagon-like peptide-1 (GLP-1) receptor agonists or dual gastric inhibitory polypeptide (GIP)/GLP-1 receptor agonists leads to a substantial regain of lost weight

Resistance training during weight loss with these compounds serves multiple purposes beyond muscle preservation

Abbreviations ACM: Arrhythmogenic cardiomyopathy DCM: Dilated cardiomyopathy DOX: Doxorubicin PKG: Cyclic GMP-dependent protein kinase PTEN: Phosphatase and tensin homolog RSV: Respiratory syncytial virus VEGF-B: Vascular endothelial growth factor AMPK: AMP-activated protein kinase EndMT: Endothelial-mesenchymal transition YAP: Yes-associated protein DEX: Dexrazoxane MDA: Malonaldehyde LEVO: Levothyroxine FOXO: Forkhead box O AMP: Adenosine monophosphate TLR: Toll-like receptors ATF: Activating transcription factor IRE: Iron responsive element References Wexler R, Elton T, Pleister A, Feldman D (2009) Cardiomyopathy: an overview

This pricing model removes the financial barrier to dose optimization: your prescription can increase as your body adapts, and your monthly cost stays constant