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This increase in lipophilicity may facilitate the molecules passive diffusion or uptake through mechanisms such as lipid raft-mediated endocytosis, which may circumvent the tight junctions that typically restrict entry into the brain

Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress

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Use of Medications: Certain medications, especially nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin or ibuprofen, can irritate the stomach lining