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Hobart says that shouldnt be a patients only priority
Cardiovascular benefits have been demonstrated in clinical trials for specific GLP-1 receptor agonists, with liraglutide, semaglutide, and dulaglutide showing reductions in major adverse cardiovascular events in patients with established cardiovascular disease or high cardiovascular risk
Sitagliptin protects rat kidneys from acute ischemia-reperfusion injury via upregulation of GLP-1 and GLP-1 receptors
The biological objective is to shift efficacy away from Cmax-limited GLP-1 signaling toward exposure- and residence-timedriven pharmacology, while preserving controlled, functionally relevant GIP co-activation
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