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Thus, studies in mice have revealed a multistep metaorganismal pathway that is initiated by sequential gut microbiotadependent conversions of oral l-carnitine into an atherogenic intermediate, BB, which is then converted into TMA, the immediate precursor for host hepatic transformation into TMAO (i.e., l-carnitine BBTMATMAO)

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Phenols, as widespread secondary metabolites in plants, have significant biological activities, but their efficacy is often limited by self-deficiency such as low absorption of curcumin, poor stability of resveratrol, and easy and rapid degradation of SalB, which leads to insufficient bioavailability

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