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GSEA analysis on the effect of tirzepatide on fatty acid metabolism showed that tirzepatide treatment exerted no significant effect on the mRNA expression of genes involved in fatty acid synthesis (SREBP2, FASN, ACC1, and SCD-1), fatty acid transport (FATP4 and FATP5), lipolysis (Mgll, Lipe, and ATGL), or inflammation (TNF, IL-1, and IL-6), suggesting that tirzepatide has limited effects on multiple metabolic pathways. Since metabolic dysregulation in MASLD also involves the extra-hepatic tissues, the authors analyzed the effect of tirzepatide on white & brown adipose tissues and skeletal muscle
Binding these receptors promotes the compensatory production of natural endorphins which then have the ability to affect the bodys immune system and slow the production of cells that can negatively influence various medical conditions
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