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These monotherapy results established proof of concept that amylin receptor agonism alone can produce clinically meaningful weight reduction and informed the dose selection of 2.4 mg for the combination product CagriSema

In fact, apart from ensuring direct access through the mucin, it was this recognition (of such a low 2-3uM solubility for niclosamide at neutral pH), that went into the initial thinking (see Supplemental Information S1 ) and prompted the invention and development of a niclosamide solution as opposed to any microparticle formulation that were all explored in the series of provisional patents (48)

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