The alpha-glucosidase inhibitor miglitol increases hepatic CYP7A1 activity in association with altered short-chain fatty acid production in the gut of obese diabetic mice
Studies have found that high NNMT expression promotes the release of inflammatory factors in adipose tissue, and NNMTi can effectively alleviate adipose inflammation and improve the microenvironment by inhibiting NNMT
LDLR is a member of the LRP family, composed of seven structurally similar transmembrane proteins, including LRP1, LRP1b, LRP2, LRP4, LRP8, VLDLR, and LDLR (May et al., 2007)
Tissue Eng Regen Med 21:97109 Zhang W, Sun G, Likhodii S, Liu M, Aref-Eshghi E, Harper PE, Martin G, Furey A, Green R, Randell E et al (2016) Metabolomic analysis of human plasma reveals that arginine is depleted in knee osteoarthritis patients