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Insulin-resistant pathways are associated with disease activity in rheumatoid arthritis and are subject to disease modification through metabolic reprogramming: a potential novel therapeutic approach

97 Thus far, six siRNA drugs have received international approval

MTC's weight loss maintenance program emphasizes follow-up, accountability, and adjustment as health and lifestyle needs change

This network underscores the essential role of bidirectional microbiotametaboliteimmune crosstalk in SLE and provides a rationale for targeted interventions (such as FMT, probiotics, metabolite supplementation, etc.), aiming to restore immune homeostasis through multiple pathways (Fig