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In recent years, accumulating evidence suggests that oxidative stress, mitochondrial dysfunction, and disturbances in iron homeostasis serve as upstream triggers driving these pathological cascades (Luo et al., 2019

Your (sensible) options are- Cosmelan peel (focal areas, such as the face, neck, chest) Vi Precision Plus (face/neck)) Melanopro Peel (face/neck) AHA peels for the face, neck or decolletage Lactic acid serum or creams for the body & limbs Your treating clinician will advise you of the best treatment option for your type of pigmentation

Treating folate deficiency Folate deficiency can happen for many reasons

Additionally, caloric restriction itself may contribute to cold sensitivity