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While GLP-1-based treatments have proven benefits for blood glucose and weight management, as well as reducing the risk of complications for people with type 2 diabetes, they are not yet approved for those with type 1, as needed trials are still ongoing

Zepbound's self-pay price, for example, starts at $299 per month and rises to $449 per month for a common maintenance dose

In animal studies, adverse renal pelvic and tubular dilatations, that were not fully reversible, were observed in rats when dapagliflozin (a component of dapagliflozin and saxagliptin) was administered during a period of renal development corresponding to the late second and third trimesters of human pregnancy, at all doses tested