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Serious allergic reactions happen in less than 1% of cases but can include throat swelling, severe rash, and breathing difficulty requiring immediate emergency care

If youre not comfortable with traditional needles, its worth knowing about alternatives that can make your treatment easier

According to the regulatory guidelines, it is also pinpointed that development should consider immunogenicity and impairment of organs, including renal and hepatic function, which may affect drug metabolism and safety

Consequently, a perfect storm of conditions can develop that pushes the pre-existing condition of low oxygen tension in the kidney into the realm of hypoxia (figure 1)