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It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway

By being proactive about their nutrition, they can stay healthy, enjoy a good quality of life, and make the most of their weight loss

That histamine, in turn, causes blood vessels to leak, leading to swollen, itchy hives

Most patients feel more energized, focused, and balanced throughout the week