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You should not stop semaglutide without consulting your healthcare provider

A systemic review in European Psychiatry found that GLP-1s can ease depressive symptoms and anxiety by reducing brain inflammation and stabilizing mood signaling

TRIUMPH-1, the pivotal obesity trial, reported on May 21, 2026 , and TRIUMPH-2 (obesity in type 2 diabetes) and TRIUMPH-3 (obesity with established cardiovascular disease) both reported on July 23, 2026 so the core evidence package for this filing is in hand