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Furthermore, oxidative stress can impede the nucleoplasmic translocation of pancreaticoduodenal homeobox factor 1 (PDX-1), impair energy metabolism, and reduce insulin production and release (Duni et al., 2019)

Other factors that could lead to B12 deficiency are: Lack of adequate production of the intrinsic factor needed for B12 absorption B12 deficiency is common in elderly people as absorption of the vitamin reduces with age People who have had any intestinal surgery, such as that for weight loss Those with gut conditions such as Crohn's Disease, inflammatory bowel disease, or celiac disease SLIDESHOW See Slideshow Vitamin B12 injections Vitamin B12 supplements are given based on the condition that causes deficiency