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No adverse effects were reported, but rigorous, large-scale trials are lacking, according to NIH

This preparation is contraindicated in patients who are sensitive to cobalt and/or vitamin B12

Only one study in patients with gastro-esophageal reflux disease (GERD) took the effort of comparing CLE to classical Ussing chamber experiments, which showed no differentiation between GERD and controls by probe-based CLE and no correlation of CLE findings and ex vivo permeability (51)