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Br J Pharmacol 2022

The medication helps the pancreas release insulin when blood glucose levels rise, reduces the amount of sugar released by the liver, and slows down how quickly food leaves the stomach, though some patients may experience constipation or, in rare cases, pancreatitis

In 2023 the firm abandoned development of lotiglipron after trial participants showed elevated liver enzymes, and the same year discontinued a twice-daily danuglipron dosing regime after almost three quarters of treated patients experienced nausea, while almost a half developed vomiting and a quarter diarrhoea

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