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Researchers believe it may be partly responsible for the decline in tissue regeneration capacity, skin elasticity, hair density, and immune function that characterize biological aging

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There was also a trend toward higher Gip expression in both sexes, which aligned with a recent report showing that insulin receptor signaling in IECs specifically regulates postprandial GIP but not GLP-1 (57)

It has been shown to upregulate pathways tied to collagen and glycosaminoglycan synthesis, modulate metalloproteinase (MMP) and tissue inhibitor of metalloproteinases (TIMP) balance, and support antioxidant effects, thereby contributing to matrix organization and structural stability in research settings