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369,370 It suppresses appetite primarily through stimulation of norepinephrine release from the hypothalamus (a brain region involved in hunger), though its stimulation of the sympathetic nervous system outside of the brain results in increased energy expenditure at rest and increased fat burning

If you're experiencing symptoms of deficiency, follow a plant-based diet, are over 50, or take medications that interfere with B12, annual testing is a good idea

Age also influences metabolic response, as older adults naturally have lower basal metabolic rates and may experience different weight loss trajectories compared to younger patients, though clinical trials have demonstrated efficacy across age groups

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