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Conclusions L-carnitine supplementation seems to be promising in reducing the frequency, duration, and severity of cirrhotic muscle cramps, a complication observed in 27.8% of the patients in our cohort
However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007
Among plans that do cover weight-loss medications, it appears that most plans require prior authorization
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