where was glp 1 discovered A timeline of GLP- discovery and clinical development. Created in Evolution of GLP-1 receptor agonists

Glucagon receptor agonism Glucagon receptor activation increases energy expenditure, improves liver health, delays gastric emptying, and promotes fat breakdown

Under the brand name Zepbound, it's approved to treat obesity, while under the brand name Mounjaro, it's approved to treat type 2 diabetes

How It Works

GLP-1R signaling regulates brain energy homeostasis and may improve mitochondrial function in depression In addition to the disturbed neuroimmune and neuroendocrine crosstalk, disruptions in brain metabolism and mitochondrial functions seem to be an emergent field of interest in the context of depression pathogenesis