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During the drug holiday Caloric needs will increase during the break as appetite returns

Competing Interests The authors have no conflict of interest to declare

Concentrated, buffer exchanged sample was lastly purified by size exclusion chromatography (SEC) at 4 C by injecting sample onto a Superose 6 Increase 10/300 GL column (GE Healthcare) equilibrated in SEC buffer (50 mM Tris, 300 mM NaCl, pH 7.0) supplemented with either 0.01% LMNG/0.001%CHS or 0.06% digitonin and immediately used for biochemical assay or cryo-EM grid preparation following quantification by BCA Assay (Pierce)

Ivermectin has recently received FDA and EU approval for the treatment of adult patients with inflammatory lesions of rosacea, a disease in which this agent has been shown to be well tolerated