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Secondly, the relative orientations and distance of two membrane-proximal regions are also significantly different between these two complexes, which to a certain extent could explain why HGF and NK1 have different ability in triggering c-MET activation

8.1.3 Network biology approach While pathway analysis highlights the dysregulated processes, network-based approaches extend this by mapping the interaction between genes, proteins, and molecular regulators within complex cellular systems, offering a complete holistic view of system-level changes (287, 288)

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Melan-A, a marker that recognizes normal melanocytes as well as antigens present on melanomas, was detected in the present study in some epithelial cells