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Oral dosing runs higher than injectable to compensate for reduced absorption

Overexpression of CerS2 has been reported to reduce mitochondrial membrane potential compared to control groups (Qiu et al., 2018)

These characteristics correlate with an increased susceptibility to infections and allergies in the neonatal period ( Of the total content of amino acids (AAs) in human milk, 510% is present in free form

For the mass spectrometry, the data-dependent MS 2 scan conditions were applied in both positive and negative mode: the scan range was from m/z 2501500, resolution was 60,000 for MS, and 30,000 for DDMS 2 (top 10), and the AGC target was 3E 6 for full MS and 1E 5 for DDMS 2 , allowing ions to accumulate for up to 200 ms for MS and 50 ms for MS/MS