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In OA FLS, integrin v6 plays a critical role due to its upregulated expression upon TGF-1 stimulation and in mediating the activation of TGF-

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Reproductive health research reveals significant applications in studying age-related endocrine dysfunction, with laboratory studies showing that FOXO4-DRI improves the testicular microenvironment and alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged male mice